Molecular studies of the atrial natriuretic factor gene.

نویسندگان

  • C E Seidman
  • K D Bloch
  • J Zisfein
  • J A Smith
  • E Haber
  • C Homcy
  • A D Duby
  • E Choi
  • R M Graham
  • J G Seidman
چکیده

The molecular biology of human atrial natriuretic factor was studied. A cloned rat cDNA probe was used to analyze tissue for the synthesis of atrial natriuretic factor, and the human gene was identified and sequenced. Nucleotide sequence comparison of human and rodent atrial natriuretic factor genes suggests regions that are critical for regulated expression of this cardiac hormone.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Extracellular Calcium Depletion on Atrial Natriuretic Factor Secretion and Gene Expression

     Extracellular Ca 2+ <span style="color: #231f20; font-family: Times ...

متن کامل

Evaluation of Serum Levels of N-terminal Pro Brain Natriuretic Peptide and Atrial Natriuretic Peptide in Neonates with Respiratory Distress

Background: Acute respiratory distress (ARD) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. The aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of N-terminal pro brain natriuretic peptide (NT-pro BNP) and Atrial natriuretic peptide(ANP) in neonates...

متن کامل

Isolated atrial amyloidosis and the importance of molecular classification.

Amyloid is identified microscopically as an amorphous extracellular hyaline material that exhibits "apple-green" birefringence with Congo red stains. Amyloid is not a chemically distinct entity, and currently available molecular methods are capable of identifying over 20 amyloidogenic precursor proteins. Some of the more common diseases associated with amyloidosis include plasma cell dyscrasias...

متن کامل

Evaluation of cardiac troponin I, atrial natriuretic peptide and some oxidative/antioxidative biomarkers in the serum and hemolysate of trained Arabian horses after exercise

Background: Limited information existed on performance tests in Iranian Arab horses. Aims: The objective of this study is to investigate time related changes of cardiac troponin I (cTnI), atrial natriuretic peptide (ANP) and oxidative/antioxidant biomarkers in the serum of Arabian horses before and after regular training. Methods: Blood samples were collected from jugular vein of 25 Arabian hor...

متن کامل

Atrial natriuretic factor. Is it physiologically important?

T he heart as an endocrine gland was unequivocally established with the ingenious experiments of DeBold and coworkers 1981 that demonstrated the existence of atrial natriuretic factor (ANF).1 These and subsequent studies have reported that ANF exists as a prepro-ANF molecule that is stored as a 126-amino-acid pro-ANF within atrial granules.2,3 In response to atrial stretch, pro-ANF is cleaved b...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Hypertension

دوره 7 3 Pt 2  شماره 

صفحات  -

تاریخ انتشار 1985